Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TTLL3 |
| Gene Name: | TTLL3 |
| Protein Full Name: | Tubulin monoglycylase TTLL3 |
| Alias: | HOTTL;Tubulin--tyrosine ligase-like protein 3 |
| Mass (Da): | 87414 |
| Number AA: | 772 |
| UniProt ID: | Q9Y4R7 |
| Locus ID: | 26140 |
| COSMIC ID: | TTLL3 |
| Gene location on chromosome: | 3p25.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20120 |
| Percent of cancer specimens with mutations: | 0.49 |
| Normal role description: | Involved in the side-chain initiation step of the glycylation reaction. Modifies alpha- and beta-tubulin by generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail. |