Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PCDHB15 |
| Gene Name: | PCDHB15 |
| Protein Full Name: | Protocadherin beta-15 |
| Alias: | PCDBF; PCDH-beta15; Protocadherin beta 15 |
| Mass (Da): | 86329 |
| Number AA: | 787 |
| UniProt ID: | Q9Y5E8 |
| Locus ID: | 56121 |
| COSMIC ID: | PCDHB15 |
| Gene location on chromosome: | 5q31 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19692 |
| Percent of cancer specimens with mutations: | 1.33 |
| Normal role description: | The PBAF complex is required for transcription of genes activated by hormone receptors. PBRM1 primarily functions to negatively regulate cell proliferation and is suggested to be a tumour suppressor protein. As such, dysfunction of PBRM1 caused by truncation or deletion mutations have been heavily implicated in the development of renal cancers. |
| Commentary on involvement of protein in cancer: | No entry in Atlasgeneticsoncology.org |