Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | WIF1 |
| Gene Name: | WIF1 |
| Protein Full Name: | Wnt inhibitory factor 1 |
| Mass (Da): | 41528 |
| Number AA: | 379 |
| UniProt ID: | Q9Y5W5 |
| Locus ID: | 11197 |
| COSMIC ID: | WIF1 |
| Gene location on chromosome: | 12q14.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20175 |
| Percent of cancer specimens with mutations: | 0.4 |
| Gene undergoes hypermethylation: | Promoter hypermethylation in breast-, nasopharyngeal-, esophageal-, lung-, and gastric cancer, various leukemias etc |
| Normal role description: | WIF1 is a secreted regulatory protein that binds to WNT proteins and inhibits their activities. It may also be involved in mesoderm segmentation. It functions as a tumour suppressor gene, and has been found to be epigenetically silenced in various cancers. |
| Commentary on involvement of protein in cancer: | 1/145 lung cancer sample was also mutated (Sanger COSMIC) |