Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | LHFP |
| Gene Name: | LHFP |
| Protein Full Name: | Lipoma HMGIC fusion partner |
| Mass (Da): | 21598 |
| Number AA: | 200 |
| UniProt ID: | Q9Y693 |
| Locus ID: | 10186 |
| COSMIC ID: | LHFP |
| Gene location on chromosome: | 13q12 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20262 |
| Percent of cancer specimens with mutations: | 0.27 |
| Deregulated in translocations: | HMGA2 -> LHFP translocation in solitary lipomas |
| Normal role description: | LHFP is a tetraspanning transmembrane protein, which is often found fused to HMGIC in lipomas. |
| Commentary on involvement of protein in cancer: | 1/185 breast- and 1/145 lung cancer samples were also mutated (mis-sense) |