Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TACC3 |
| Gene Name: | TACC3 |
| Protein Full Name: | Transforming acidic coiled-coil-containing protein |
| Alias: | ERIC1; ERIC-1; TAC3; Transforming acidic coiled-coil-containing protein 3; Transforming, acidic coiled-coil containing protein 3 |
| Mass (Da): | 90360 |
| Number AA: | 838 |
| UniProt ID: | Q9Y6A5 |
| Locus ID: | 10460 |
| COSMIC ID: | TACC3 |
| Gene location on chromosome: | 4p16.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.58 |
| Normal role description: | TACC3 is invovled in chromosomeal alignment, segregation, cytokineses and and regulation of p53 mediated apoptosis. It is also involved in transcriptional regulation of FOG1 and CREB. Overexpression and reduced expression is seen in various cancers. |