Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MRVI1 |
| Gene Name: | MRVI1 |
| Protein Full Name: | Protein MRVI1 |
| Alias: | Inositol 1,4,5-triphosphate-associated cGMP kinase substrate; IP3R-associated cGMP kinase substrate; IRAG; JAW1L; JAW1-related protein; Murine retrovirus integration site 1; Retrovirus integration site 1 homolog |
| Mass (Da): | 96145 |
| Number AA: | 885 |
| UniProt ID: | Q9Y6F6 |
| Locus ID: | 10335 |
| COSMIC ID: | MRVI1 |
| Gene location on chromosome: | 11p15 |
| Number of cancer specimens: | 19558 |
| Percent of cancer specimens with mutations: | 0.76 |
| Commentary on involvement of protein in cancer: | Play a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. |