Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NCOA3 |
| Gene Name: | NCOA3 |
| Protein Full Name: | Nuclear receptor coactivator 3 |
| Alias: | ACTR; AIB1; AIB-1; Amplified in breast cancer-1 protein; BHLHe42; CAGH16; CBP-interacting protein; KAT13B; NCO3; NCoA-3; P/CIP; PCIP; RAC3; RAC-3; Receptor-associated coactivator 3; SRC3; SRC-3; Steroid receptor coactivator protein 3; Thyroid hormone receptor activator molecule 1; TNRC16; TRAM1; TRAM-1 |
| Mass (Da): | 155293 |
| Number AA: | 1424 |
| UniProt ID: | Q9Y6Q9 |
| Locus ID: | 8202 |
| COSMIC ID: | NCOA3 |
| Gene location on chromosome: | 20q12; 20q13.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 1.33 |
| Found in amplified chromosomal regions in human cancers: | Heptacellular carcinoma, Breast cancer and Ovarian Cancer. |
| Normal role description: | NCOA3 is a tanscriptional coactivator which faciliate nuclear receptor mediated transcription of target genes. NCOA3 will bind to nuclear receptors to enhance transcripional activation. NCOA3 will activate transcription through its acetyltransferase activity to cause chromatin remodeling and through recruitment of transcription activator complex components such as CREB Binding Protein (CBP)/p300. Aberrant expression of NCOA3 through amplification has been implicated in several cancers. Overexpression of NCOA3 may lead to increased transcriptional activation of oncogenes. Increased expression of NCOA3 have been observed in breast, ovarian, endometrial, gastric and pancreatic cancers. |