Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DUSP10 |
| Gene Name: | DUSP10 |
| Protein Full Name: | Dual specificity protein phosphatase 10 |
| Alias: | Dual specificity protein phosphatase 10; DUS10; DUSP10; EC 3.1.3.16; EC 3.1.3.48 |
| Mass (Da): | 52642 |
| Number AA: | 482 |
| UniProt ID: | Q9Y6W6 |
| Locus ID: | 11221 |
| COSMIC ID: | DUSP10 |
| Gene location on chromosome: | 1q41 |
| Cancer protein type: | TSP (possibly) |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBIT |
| Number of cancer specimens: | 20150 |
| Percent of cancer specimens with mutations: | 0.5 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | DUSP10 is a protein-dual specificity phosphatase. It may be involved in the inactivation of MAP kinases, specifically for MAPK11/12/13/14. It can also dephosphorylate NK and p38. However, to date there have been no associations between DUSP10 levels and cancer. |