Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PIAS3 |
| Gene Name: | PIAS3 |
| Protein Full Name: | E3 SUMO-protein ligase PIAS3 |
| Alias: | Protein inhibitor of activated STAT 3 |
| Mass (Da): | 68017 |
| Number AA: | 628 |
| UniProt ID: | Q9Y6X2 |
| Locus ID: | 10401 |
| COSMIC ID: | PIAS3 |
| Gene location on chromosome: | 1q21.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBIT |
| Number of cancer specimens: | 20238 |
| Percent of cancer specimens with mutations: | 0.51 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | PIAS3 is a E3-type small ubiquitin-like modifier ligase. It plays a crucial role in transcriptional coregulation of various pathways including JAK-STAT pathway and steroid hormone signalling. It can inhibit STAT3, a transcription factor activated following activation of growth factor receptors such as EGFR, from binding to DNA and block the transcription of growth-promoting genes. It can also block NF-kB mediated transcription. PIAS3 appears to have a role in facilitate apoptosis as well. |