Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CAMTA1 |
| Gene Name: | CAMTA1 |
| Protein Full Name: | Calmodulin-binding transcription activator 1 |
| Alias: | Calmodulin binding transcription activator 1; CMTA1; KIAA0833 |
| Mass (Da): | 183672 |
| Number AA: | 1673 |
| UniProt ID: | Q9Y6Y1 |
| Locus ID: | 23261 |
| COSMIC ID: | CAMTA1 |
| Gene location on chromosome: | 1p36.31 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBIT |
| Number of cancer specimens: | 19659 |
| Percent of cancer specimens with mutations: | 1.82 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | CAMTA1 may be a transcriptional activator with potential roles as a tumour suppressor, but its specific function is unclear. Expression levels appear to fluctuate according to the cell cycle phase, with high expression during S and M phase and low expression during G0 and G1 phases. Low expression has been associated with neuroblastoma, glioma, and colon cancers. |